Publications | Yongsoo Park Lab

^#, Corresponding author.
1. Shin KC, Ali Moussa HY, Park Y^#. Cholesterol imbalance and neurotransmission defects in neurodegeneration. Exp Mol Med. 2024 Aug 1. Review.
2. Ali G, Shin KC, Ahmed N, Habbab W, Alkhadairi G, Razzaq A, Bejaoui Y, El Hajj N, Mifsud B, Park Y, Stanton LW. Deletion in RMST lncRNA impairs hypothalamic neuronal development in a human stem cell-based model of Kallmann Syndrome. Cell Death Discov. 2024 Jul 19;10(1):330.
3. Ali Moussa HY, Shin KC, Ponraj J, Park SH, Lee OS, Mansour S, Park Y^#. PIP₂ Is an electrostatic Catalyst for Vesicle Fusion by Lowering the Hydration Energy: Arresting Vesicle Fusion by Masking PIP₂. ACS Nano. 2024, 18, 20, 12737-12748. Highlighted as a supplementary Cover.
4. Salloum-Asfar S, Shin KC, Taha RZ, Khattak S, Park Y, Abdulla SA. The potential role of thyroid hormone therapy in neural progenitor cell differentiation and its impact on neurodevelopmental disorders. Mol Neurobiol. 2024 Jun;61(6):3330-3342.
5. Ali G, Shin KC, Habbab W, Alkhadairi G, AbdelAleem A, AlShaban FA, Park Y, Stanton LW. Characterization of a loss-of-function NSF attachment protein beta mutation in monozygotic triplets affected with epilepsy and autism using cortical neurons from proband-derived and CRISPR-corrected induced pluripotent stem cell lines. Front Neurosci. 2023;17:1302470.
6. Shin KC, Ali G, Ali Moussa HY, Gupta V, de la Fuente A, Kim HG, Stanton LW, Park Y^#. Deletion of TRPC6, an autism risk gene, induces hyperexcitability in cortical neurons derived from human pluripotent stem cells. Mol Neurobiol. 2023 Dec;60(12):7297-7308.
7. Ali Moussa HY, Shin KC, Ponraj J, Kim SJ, Ryu JK, Mansour S, Park Y^#. Requirement of cholesterol for calcium-dependent vesicle fusion by strengthening synaptotagmin-1-induced membrane bending. Adv Sci. 2023 May;10(15):e2206823. Highlighted as a Frontispiece.
8. Ali Moussa HY, Park Y^#. Electrostatic regulation of the cis- and trans-membrane interactions of synaptotagmin-1. Sci Rep. 2022 Dec 27;12(1):22407.
9. Ben-Mahmoud A, Jun KR, Gupta V, Shastri P, de la Fuente A, Park Y, Shin KC, Kim CA, da Cruz AD, Pinto IP, Minasi LB, Silva da Cruz A, Faivre L, Callier P, Racine C, Layman LC, Kong IK, Kim CH, Kim WY, Kim HG. A rigorous in silico genomic interrogation at 1p13.3 reveals 16 autosomal dominant candidate genes in syndromic neurodevelopmental disorders. Front Mol Neurosci. 2022 Oct 6;15:979061.
10. Ali Moussa HY, Manaph N, Ali G, Maacha S, Shin KC, Ltaief SM, Gupta V, Tong Y, Ponraj J, Salloum-Asfar S, Mansour S, Al-Shaban FA, Kim HG, Stanton LW, Grivel JC, Abdulla SA, Al-Shammari AR^#, Park Y^#. Single extracellular vesicle analysis using flow cytometry for neurological disorder biomarkers. Front Integr Neurosci. 2022 May 17;16:879832.
11. Tastan B, Tarakcioglu E, Birinci Y, Park Y, GENÇ Ş. Role of Exosomal MicroRNAs in Cell-to-Cell Communication. Methods Mol Biol. 2022;2257:269-292.
12. Birinci Y, Preobraschenski J, Ganzella M, Jahn R^#, Park Y^#. Isolation of large dense-core vesicles from bovine adrenal medulla for functional studies. Sci Rep. 2020 May 5;10(1):7540.
13. Hubrich R, Park Y, Mey I, Jahn R, Steinem C. SNARE-mediated fusion of single chromaffin granules with pore-spanning membranes. Biophys J. 2019 Jan 22;116(2):308-318.
14. Park Y^# and Ryu JK^#. Models of synaptotagmin-1 to trigger Ca2+-dependent vesicle fusion. FEBS Lett. 2018 Nov;592(21):3480-3492.
15. Park Y^#, MicroRNA exocytosis by vesicle fusion in neuroendocrine cells. Front Endocrinol. 2017 Dec 22;8:355.
16. Gümürdü A, Yildiz R, Eren E, Karakülah G, Ünver T, GENÇ Ş, and Park Y^#. MicroRNA exocytosis by large dense-core vesicle fusion. Sci Rep. 2017 Mar 30;7:45661.
17. Park CG, Park Y, Suh BC. The HOOK region of voltage-gated Ca2+ channel β subunits senses and transmits PIP2 signals to the gate. J Gen Physiol. 2017 Feb;149(2):261-276.
18. Kim DI, Kweon HJ, Park Y, Jang DJ, Suh BC. Ca2+ controls gating of voltage-gated calcium channels by releasing the β2e subunit from the plasma membrane. Sci Signal. 2016 Jul 5;9(435):ra67.
19. Park Y, Seo JB, Fraind A, Pérez-Lara A, Yavuz H, Han K, Jung SR, Kattan I, Walla PJ, Choi MY, Cafiso DS, Koh DS, Jahn R. Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength. Nature Struct Mol Biol. 2015 Oct;22(10):815-823.
20. Kim DI, Kang M, Kim S, Lee J, Park Y, Chang I, Suh BC. Molecular Basis of the Membrane Interaction of the β2e Subunit of Voltage-Gated Ca(2+) Channels. Biophys J. 2015 Sep 1;109(5):922-935.
21. Kim DI, Park Y, Jang DJ, Suh BC. Dynamic phospholipid interaction of β2e subunit regulates the gating of voltage-gated Ca2+ channels. J Gen Physiol. 2015 Jun;145(6):529-541.
22. Ryu JK, Min D, Rah SH, Kim SJ, Park Y, Kim H, Hyeon C, Kim HM, Jahn R, Yoon TY. Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover. Science. 2015 Mar 27;347(6229):1485-1489.
23. Kim KH, Jun YW, Park Y, Lee JA, Suh BC, Lim CS, Lee YS, Kaang BK, Jang DJ. Intracellular membrane association of Aplysia cAMP phosphodiesterase long- and short-form via different targeting mechanisms. J Biol Chem. 2014 Sep 12; 289(37): 25797-25811.
24. Park Y, Vennekate W, Yavuz H, Preobraschenski J, Hernandez JM, Riedel D, Walla PJ, Jahn R. α-SNAP interferes with the zippering of the SNARE membrane fusion machinery. J Biol Chem. 2014 Jun 6;289(23):16326-16335.
25. Kim DC, Yun SJ, Park YS, Jun DJ, Kim D, Jiten Singh N, Kim S, Kim KT. Pyrilamine inhibits nicotine-induced catecholamine secretion. Neurochem Int. 2014 Jul;74:42-45.
26. Park Y, Hernandez J. M, van den Bogaart G, Ahmed S, Holt M, Riedel D, and Jahn R. Controlling synaptotagmin activity by electrostatic screening. Nature Struct Mol Biol. 2012 Oct;19(10):991-997.
27. Park Y and Kim KT. Dominant role of lipid rafts L-type calcium channel in activity-dependent potentiation of large dense-core vesicle exocytosis. J Neurochem. 2009 Jul;110(2):520-529.
28. Park Y and Kim KT. Short-term plasticity of small synaptic vesicle (SSV) and large dense-core vesicle (LDCV) exocytosis. Cell Signal. 2009 Oct;21(10):1465-70.
29. Park YS, Choi YH, Park CH, Kim KT. Non-genomic glucocorticoid effects on activity-dependent potentiation of catecholamine release in chromaffin cells. Endocrinology. 2008 Oct;149(10):4921-7.
30. Jun DJ, Kim J, Jung SY, Song R, Noh JH, Park YS, Ryu SH, Kim JH, Kong YY, Chung JM, and Kim KT. Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors. J. Biol. Chem. 2007 Dec 28;282(52):37350-8.
31. Park YS, Hur EM, Choi BH, Kwak E, Jun DJ, Park SJ, Kim KT. Involvement of protein kinase C-epsilon in activity-dependent potentiation of large dense-core vesicle exocytosis in chromaffin cells. J Neurosci. 2006 Aug 30;26(35): 8999-9005.
32. (Cover article) Park YS, Jun DJ, Hur EM, Lee SK, Suh BS, Kim KT. Activity-dependent potentiation of large dense-core vesicle release modulated by mitogen-activated protein kinase(MAPK)/ERK signaling. Endocrinology. 2006 Mar;147(3):1349-56.
33. Kim DC, Park YS, Jun DJ, Hur EM, Kim SH, Choi BH, Kim KT. N-(4-Trifluoromethylphenyl)amide group of the synthetic histamine receptor agonist inhibits nicotinic acetylcholine receptor-mediated catecholamine secretion. Biochem Pharmacol. 2006 Feb 28;71(5):670-82.
34. Lee BD, Kim S, Hur EM, Park YS, Kim YH, Lee TG, Kim KT, Suh PG, Ryu SH. Leumorphin has an anti-apoptotic effect by activating epidermal growth factor receptor kinase in rat pheochromocytoma PC12 cells. J Neurochem. 2005 Oct;95(1):56-67.
35. Hur EM, Park YS, Huh YH, Yoo SH, Woo KC, Choi BH, Kim KT. Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling. J Cell Biol. 2005 May 23;169(4):657-67.
36. Woo KC, Park YS, Jun DJ, Lim JO, Baek WY, Suh BS, Kim KT. Phytoestrogen cimicifugoside-mediated inhibition of catecholamine secretion by blocking nicotinic acetylcholine receptor in bovine adrenal chromaffin cells. J Pharmacol Exp Ther. 2004 May;309(2):641-9.
37. Hur EM, Park YS, Lee BD, Jang IH, Kim HS, Kim TD, Suh PG, Ryu SH, Kim KT. Sensitization of epidermal growth factor-induced signaling by bradykinin is mediated by c-Src. Implications for a role of lipid microdomains. J Biol Chem. 2004 Feb 13;279(7):5852-60.
38. Park TJ, Park YS, Lee TG, Ha H, Kim KT. Inhibition of acetylcholine-mediated effects by borneol. Biochem Pharmacol. 2003 Jan 1;65(1):83-90.

Publications (ORCID: 0000-0001-8336-8051)